KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK6
All Species:
36.67
Human Site:
Y24
Identified Species:
57.62
UniProt:
Q00534
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00534
NP_001138778.1
326
36938
Y24
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
T19
I
G
V
G
A
Y
G
T
V
Y
K
A
R
D
P
Dog
Lupus familis
XP_852360
326
36788
Y24
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
Cat
Felis silvestris
Mouse
Mus musculus
Q64261
326
37010
Y24
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
Rat
Rattus norvegicus
P35426
303
33780
S28
Y
K
A
R
D
P
H
S
G
H
F
V
A
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511310
202
22667
Chicken
Gallus gallus
P13863
303
34670
Y19
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
Frog
Xenopus laevis
Q91727
319
35666
Y20
A
E
I
G
V
G
A
Y
G
T
V
Y
K
A
R
Zebra Danio
Brachydanio rerio
NP_001137525
302
33962
Y21
A
E
I
G
E
G
A
Y
G
K
V
Y
K
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477196
317
36383
Y37
N
I
I
G
E
G
A
Y
G
T
V
Y
R
A
R
Honey Bee
Apis mellifera
XP_391955
457
50351
Y165
S
L
I
G
N
G
A
Y
G
T
V
Y
K
A
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
Y25
A
E
I
G
S
G
A
Y
G
I
V
Y
K
A
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
Y19
E
G
T
Y
G
V
V
Y
K
A
L
D
K
A
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
Y19
E
G
T
Y
G
V
V
Y
K
A
R
D
K
V
T
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
Y19
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
65.6
96.6
N.A.
96.3
65
N.A.
56.1
43.5
65.3
76
N.A.
42.6
37.6
N.A.
50.6
Protein Similarity:
100
N.A.
76
97.5
N.A.
98.1
76
N.A.
58.5
61.9
77.9
83.1
N.A.
63.7
50.5
N.A.
63
P-Site Identity:
100
N.A.
6.6
100
N.A.
100
6.6
N.A.
0
13.3
80
93.3
N.A.
66.6
60
N.A.
80
P-Site Similarity:
100
N.A.
20
100
N.A.
100
26.6
N.A.
0
13.3
86.6
100
N.A.
80
80
N.A.
86.6
Percent
Protein Identity:
N.A.
44.4
N.A.
44.7
40.1
N.A.
Protein Similarity:
N.A.
62.2
N.A.
62.2
59.8
N.A.
P-Site Identity:
N.A.
20
N.A.
13.3
53.3
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
13.3
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
40
0
7
0
7
0
54
0
0
14
0
7
7
67
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
0
0
0
14
0
7
0
% D
% Glu:
27
40
0
0
40
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
7
20
0
0
0
% F
% Gly:
0
27
0
67
20
60
7
0
67
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
7
0
0
7
0
7
0
0
0
% H
% Ile:
7
7
54
0
0
0
0
0
0
7
0
0
0
0
0
% I
% Lys:
0
14
0
0
0
0
0
0
20
27
7
0
74
0
14
% K
% Leu:
0
7
0
0
0
0
0
0
0
0
7
0
0
7
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
14
0
14
0
47
% R
% Ser:
7
0
0
0
7
0
0
7
0
0
0
0
0
0
0
% S
% Thr:
0
0
20
0
0
0
7
7
0
20
0
0
0
7
20
% T
% Val:
0
0
14
0
7
20
20
0
7
7
60
7
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
20
0
7
0
80
0
7
0
40
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _